L-Carnosine’s Fight Against Premature Aging
L-Carnosine was first discovered in Russia in 1900 and, right up until very recently, has been a curiosity known only to a few leading biochemists. Several recent studies have shown that it has many excellent health benefits.It also has superb anti-aging properties which the latest studies have apportioned to its unique ability to protect telomeres in the body; telomeres protect the end of chromosomes within the body from deterioration and help to stop them fusing with other neighbouring chromosomes.
Telomeres are small ‘zipper-like’ capsules which bind together the genetic material of our DNA and enable precise cellular reproduction. Each time a cell replicates, its telomere shortens and this diminishes the overall life-expectancy of the cell; so it can be likened to a biological counter which counts the number of times that the cell has already replicated. When there is no more telomere left then the cell has come to the end of its life-cycle and then cell-death quickly ensues. A recent study, published in the journal of Arteriosclerosis, Thrombosis & Vascular Biology, has found a direct coloration between the shortening of the telomere and the risk of developing heart disease, the chances of suffering a heart attack as well as premature death from all other causes. So, by studying telomere length, we can now help to diagnose and predict these things in advance before they happen.
It is now possible, with a simple blood test, to examine aging by measuring a person’s telomere length to reveal their body’s overall cellular wear and tear. A nineteen year long study was carried out by researchers from The University of Copenhagen in Denmark, on 20,000 Danes, to analyse their DNA and, more specifically, to measure their telomere length as an established measurement of cellular aging. The results demonstrated that when the telomere length was short, the risk of heart attack was increased by as much as 50% and the chances of premature death was increased by as much as 25%.
Smoking and obesity cause systemic inflammation and are a direct cause of shortening of the telomere. Besides improving lifestyle risks and diet, daily supplementation with L-Carnosine is a very effective way to not only block telomere shortening, but to start to actually lengthen them again as well. This very effectively reduces the effects of aging and increase longevity.
L-Carnosine’s Many Health Benefits
- Buffers Lactic Acid buffering (helps to reduce muscle “burn”).
- Very Powerful Super-Antioxidant (Quenches even the most destructive free radicals: the hydroxyl and peroxyl radicals, superoxide, and singlet oxygen.
- Potent Aldehyde scavenger (Detoxification of cytotoxic alpha, beta-unsaturated aldehydes).
- Prevents Glycation end-products (AGE) (A process where sugar and protein molecules combine to form a tangled mess of tissue).
- Prevents Carbonylation (Carbonylation is a pathological step in the age-related degradation of the body’s proteins).
- Neurotransmitter (Chemicals that transmit signals from a neuron to a target cell across a synapse in the brain).
- Chelates Ionic Heavy Metals (flush toxins from the body).
- Powerful regulator of zinc and copper concentrations in nerve cells.
- Prevents skin collagen cross-linking which leads to a loss of elasticity and wrinkles.
This previously little know super nutrient is about to become the leader in field in the fight against aging for those people who want to grow old slower and more gracefully whilst also helping to protect their bodies against all degenerative diseases.
L-Carnosine is known to work in synergy with other biological antioxidants; such as vitamin C, vitamin E, zinc and selenium and also with antioxidant enzymes such as superoxide dismutase (SOD) and catalase. This means that it has its own excellent antioxidant properties in its own right, but that it also acts with other antioxidant substances and systems to give a much greater overall benefit than the sum total of all of their separate effects combined. It also helps prevent carbonylation by “mopping up” other toxic substances, which are inevitable produced as a side effect of metabolism, such as aldehydes. These substances damage body proteins and the fats within cell membranes by irreversibly reacting with them to form biologically useless substances.
It also helps to prevent glycation; if glucose is present in high concentrations, it can also react with body proteins to form more biologically useless substances.
L-Carnosine blocks, or at least radically slows down, all of these degenerative processes and hence it very effectively slows down the effects of aging.
Alzheimer’s Disease, Parkinson’s Disease & Senile Dementia
Alzheimer’s disease is thought to be caused by abnormal versions of normal brain proteins called prions. A prion is a naturally occurring protein in its normal form but, by folding into an aberrant shape, it then turns into a rogue agent. This rogue agent then co-opts other normal prions into also becoming rogue agents themselves and thus the disease begins to spread. The trigger to change shape is caused by various forms of damage to these proteins. L-Carnosine crosses the blood-brain barrier and has been shown to be very effective at preventing this damage from happening.
Besides this, the excellent chelating properties that carnosine possesses also help to slow down the progression of Alzheimer’s disease. Patient’s suffering from Alzheimer’s disease usually have excessive levels of copper, zinc and other ionic metals present in their brains. It is thought that the excessive levels of these metals play an important role in the degenerative change of the normal proteins, called amyloid, to become the abnormal ones which are called beta-amyloid. L-Carnosine’s great ability to “mop-up” and remove these excessive amounts of metals within the brain slows down the progression of Alzheimer’s disease and also helps to reduce the symptoms. Studies have shown that L-Carnosine also protects nerve cells from damage as well as from the degenerative changes associated with Alzheimer’s Disease.
L-Carnosine is also an excellent cognitive enhancer and is a very effective way to help to train your brain. It increases both short-term and long-term memory function and promotes much sharper and clearer thinking.
Author: Peter Aldred